Genentech experience with rt-PA (activase)

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Intravenous thrombolysis with rt-PA in stroke: experience of the moroccan stroke unit

The majority of strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage has occurred. We report the case series of all patients who were treated with rt-PA at Stroke Unit of HASSAN II University hospital between 2010 and 2013. There were 52 patients treated with intravenous rtPA during the s...

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[Traumatic submacular hemorrhage treated with rt-PA and SF6].

CASE REPORT This patient was afflicted by a traumatic submacular hemorrhage. A posterior vitrectomy was performed and intravitreal rt-PA and SF6 were administered. Four weeks later, the visual acuity had increased from 0.1 to 0.8. No complications due to the treatment with rt-PA were reported. DISCUSSION It is known that waiting for the spontaneous blood removal in such cases results in a poo...

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Coronary Arterial Thrombolysis With rt-PA in a Canine Preparation

G4120, L-cysteine, A^mercaptoacetyl)-D-tyrosyl-L-arginylglycyl-L-tt-aspartyl-cyclic(l-»5)-sulfide, 5-oxide, a synthetic cyclic Arg-Gly-Asp-containing pentapeptide, has a high affinity (dissociation constant of 4 nM) for the platelet glycoprotein (GP) Ilb/IIIa receptor. The effects of its intravenous or endobronchial administration on thrombolysis, reocclusion, and bleeding time prolongation ind...

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Genentech, Inc

How did it start? It began in 1976 with a meeting over a glass of beer between Bob Swanson, then a bright young venture capitalist, and Herb Boyer (UCSF), who with Stan Cohen (Stanford) had just performed some of the key experiments of recombinant DNA technology. The meeting is now immortalized in a brass statue in the new Founders’ Research Center. Genentech was founded later that year, and cl...

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Double Thrombolysis with rt-PA in a Patient with Massive Pulmonary Embolism and Antiphospholipid Syndrome

T he antiphospholipid syndrome is an autoimmune disease, characterized by the presence of antiphospholipid antibodies, thromboses, repeat spontaneous abortions and thrombocytopenia. The syndrome may be encountered in patients without any clinical or laboratory indications of other systemic disease (primary), or may be encountered within the context of other systemic disease – more often with Sy...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 1987

ISSN: 0735-1097

DOI: 10.1016/s0735-1097(87)80408-4